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1 Polarity establishment by Cdc42: Key roles for positive ... - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380280/
Here we review recent insights into the nature of positive feedback and the mechanism of Cdc42 accumulation gained from studies in yeast model systems. Go to: ...
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2 The Small GTPase Cdc42 Is a Major Regulator of Neutrophil ...
https://www.frontiersin.org/articles/10.3389/fimmu.2020.01197/full
This review will focus on the close homologs Rac and Cdc42, which have been established as drivers of metastasis and therapy resistance in ...
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3 Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic ...
https://journals.asm.org/doi/10.1128/MMBR.63.1.54-105.1999
cerevisiae are highly conserved in other eukaryotes. Due to the abundance of recent reviews on cell polarity and signaling (26, 69, 77, 100, 126, 170, 177, 202, ...
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4 Molecular subversion of Cdc42 signalling in cancer
https://portlandpress.com/biochemsoctrans/article/49/3/1425/229140/Molecular-subversion-of-Cdc42-signalling-in-cancer
Here we review alterations found to Cdc42 itself and to key components of the signal transduction pathways it controls in cancer.
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5 The evolutionary history of effectors downstream of Cdc42 and ...
https://genomebiology.biomedcentral.com/articles/10.1186/gb-2002-3-2-reviews0002
Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate ... is attached to a GTPase-activating protein, or GAP (reviewed in [5]).
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6 Signaling Role of Cdc42 in Regulating Mammalian Physiology
https://www.jbc.org/article/S0021-9258(20)54108-2/abstract
Recent studies by conditional gene targeting of cdc42 in mice have ... These have been extensively elaborated by several excellent reviews (.
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7 Cell cycle entry triggers a switch between two modes of Cdc42 ...
https://elifesciences.org/articles/26722
Optogenetic control of Cdc42 activation during polarization of budding yeast ... The first decision letter after peer review is shown below.
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8 Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 ...
https://rupress.org/jcb/article/160/3/375/54784/Rac-and-Cdc42-play-distinct-roles-in-regulating-PI
› jcb › article › Rac-and-Cdc42-play-di...
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9 Structure of the Rho Family GTP-Binding Protein Cdc42 in ...
https://www.cell.com/abstract/S0092-8674(00)80670-4
Introduction. The Rho-related GTP-binding proteins (e.g., Cdc42, Rac, and Rho) function as tightly regulated molecular switches that govern a ...
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10 Cell Polarity in Yeast - Annual Reviews
https://www.annualreviews.org/doi/abs/10.1146/annurev-cellbio-100616-060856
A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in diverse organisms. Here we review findings from budding and fission ...
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11 Protein Cdc42 - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/protein-cdc42
From: International Review of Cell and Molecular Biology, 2013 ... Stimulation of the serotonin 5-HT7 receptor leads to activation of Cdc42 via a mechanism ...
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12 Regulating Cdc42 and Its Signaling Pathways in Cancer ...
https://www.mdpi.com/1420-3049/23/4/787/htm
Cdc42 is a member of the Rho GTPase family and plays an important role in ... This review will address the post-transcriptional regulation of Cdc42 by ...
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13 The role of cell division control protein 42 in tumor and non ...
https://www.jcancer.org/v13p0800.htm
Here, we systematically reviewed the structure, functions, and small molecule inhibitors of Cdc42 in malignant tumor and non-tumor diseases, ...
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14 Cdc42 Is Not Essential for Filopodium Formation, Directed ...
https://www.molbiolcell.org/doi/10.1091/mbc.e05-01-0061
Cdc42 is a small GTPase involved in the regulation of the cytoskeleton and cell ... role for Cdc42 in cell migration (reviewed by Fukata et al., 2003).
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15 Cdc42 Signaling Pathway Inhibition as a Therapeutic Target ...
https://www.eurekaselect.com/node/152881/article/cdc42-signaling-pathway-inhibition-as-a-therapeutic-target-in-ras-related-cancers
Methods: We review the link between Ras and Cdc42 and summarize the roles of Cdc42 and select effectors in cancers. We discuss the discovery/development of ...
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16 A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074924
Annual review of biochemistry 68: 459–486. View Article; Google Scholar. 29. Shi HY, Stafford LJ, Liu Z, Liu M, Zhang M (2007) ...
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17 A Cdc42-mediated supracellular network drives polarized ...
https://www.nature.com/articles/s41467-020-15593-2
Finally, our study shows that a Cdc42-dependent supracellular cytoskeletal ... Peer review information Nature Communications thanks the ...
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18 Cdc42 and Vesicle Trafficking in Polarized Cells
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0854.2010.01102.x
Here we review findings on the interplay between Cdc42 and trafficking in yeast,. Caenorhabditis elegans, Drosophila and mammalian cell culture ...
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19 Rho GTPases as therapeutic targets in cancer (Review)
https://www.spandidos-publications.com/10.3892/ijo.2017.4093
Up to date three members of the Rho GTPase family have been studied in detail: Cdc42, Rac1 and RhoA. These are all the classical Rho GTPases ...
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20 2225.full.pdf - The Journal of Immunology
https://www.jimmunol.org/content/jimmunol/171/5/2225.full.pdf
Every submission reviewed by practicing scientists. No Triage! ... the Activation of the Small Rho GTPase Cdc42 in Human T.
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21 CDC42 (cell division cycle 42 (GTP binding protein, 25kDa))
https://atlasgeneticsoncology.org/gene/40012/cdc42-(cell-division-cycle-42-(gtp-binding-protein-25kda))
Proteins. Description. CDC42 encodes a 21.3 kDa, 191 amino acids small GTPase protein that belongs to the Rho family of Ras GTPases superfamily.
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22 Could cell division cycle protein 42 be a target for lung cancer ...
https://tcr.amegroups.com/article/view/26580/html
Cdc42 is overexpressed in human lung cancer samples, which suggests that this protein is associated with lung carcinogenesis. Herein, we review the functions of ...
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23 Cdc42 Regulates Cofilin during the Establishment of Neuronal ...
https://www.jneurosci.org/content/27/48/13117
Neurons from the Cdc42 null animals sprouted neurites but had a strongly ... many of which regulate cytoskeletal dynamics (for review, ...
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24 Clinical relevance of the transcriptional signature regulated by ...
https://www.oncotarget.com/article/15815/text/
CDC42 is an oncogenic Rho GTPase overexpressed in colorectal cancer (CRC). ... affect a broad spectrum of cell functions (reviewed in [17]).
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25 Dmel\Cdc42 - FlyBase Gene Report
https://flybase.org/reports/FBgn0010341.html
Cell division cycle 42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular ... [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot).
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26 Excellent Immunodetection of Cdc42 Protein in Mouse Cell Line
https://www.biocompare.com/Product-Reviews/186484-Excellent-Immunodetection-of-Cdc42-protein-in-mouse-cell-line/
A review of the Excellent Immunodetection of Cdc42 Protein in Mouse Cell Line . Unbiased reviews by scientists available at Biocompare.com.
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27 YAP/TAZ-CDC42 signaling regulates vascular tip cell migration
https://www.pnas.org/doi/10.1073/pnas.1704030114
... Dallas, TX, and approved August 25, 2017 (received for review March 9, 2017) ... YAP and TAZ Regulate CDC42 Activity in Migrating Endothelial Cells.
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28 Anti-CDC42 antibody [M152] (ab41429) - Abcam
https://www.abcam.com/cdc42-antibody-m152-ab41429.html
Knockout Tested Mouse monoclonal CDC42 antibody [M152]. Validated in WB, ICC/IF and tested in Mouse, Rat, ... Independently reviewed in 5 review(s). Immunogen…
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29 International Review of Cell and Molecular Biology
https://books.google.com/books?id=jWSosav1JiIC&pg=PA318&lpg=PA318&dq=cdc42+review&source=bl&ots=3p5QPJc_PY&sig=ACfU3U3G5SkLq3M6ItgO_q_aiQfI4_4Pkg&hl=en&sa=X&ved=2ahUKEwjhkNrZ-7j7AhWiQUEAHbvuDBAQ6AF6BQjzARAD
A B GAP Dominant negative Active GTPase-activating protein Inactive GDP GEF Cdc42T17N GDP GTP Cdc42 Cdc42 Guanine nucleotide Cdc42 dissociation inhibitor C ...
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30 A systematic, cell-based comparison of G-protein binding ...
https://www.biorxiv.org/content/10.1101/2022.09.12.507573v1
A reminder: they have not been formally peer-reviewed and should not guide ... Rac and Cdc42 are Rho GTPases which regulate the formation of ...
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31 An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell ...
https://www.science.org/doi/10.1126/science.7652575
Instead, Rac and Cdc42, but not Rho, stimulated a distinct MAP kinase, the c-Jun kinase JNK/SAPK ... eLetters is an online forum for ongoing peer review.
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32 Ratiometric Imaging Using a Single Dye Enables ...
https://pubs.acs.org/doi/10.1021/jacs.5b09764
The dye was used to generate a ratiometric biosensor of Cdc42 (CRIB199) ... Review methodes of synthesis and use of merocyanine dyes. Bibl.
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33 CDC42 | SGD - Saccharomyces Genome Database
https://www.yeastgenome.org/locus/S000004219
A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are ...
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34 Cdc42, a Rho GTPase and regulator of ... - Cytoskeleton, Inc.
https://www.cytoskeleton.com/cdc42
Cdc42 is a 21 kDa small GTPase, a member of the Ras super-family and Rho sub-family of GTPases, that upon activation by a guanine nucleotide exchange factor ...
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35 Regulation of Cdc42 for polarized growth in budding yeast
http://microbialcell.com/researcharticles/2020a-miller-microbial-cell/
In budding yeast, Cdc42 activation occurs in two temporal steps in the G1 phase of the cell cycle to establish a proper growth site. Here, we review findings in ...
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36 New review in Bioessays on Cdc42 GTPase polarization
https://wp.unil.ch/martinlab/2015/09/new-review-in-bioessays-on-cdc42-gtpase-polarization/
Sophie Martin published a review in Bioessays, in which she discusses the mechanisms by which the Cdc42 GTPase, a central organizer ...
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37 CDC42 - Genomics England PanelApp
https://panelapp.genomicsengland.co.uk/panels/genes/CDC42
Green CDC42 in COVID-19 research. Level 2: Viral research. Version 1.130. review, MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown ...
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38 CDC42 Antibody (JJ086-04) (NBP2-67895) - Novus Biologicals
https://www.novusbio.com/products/cdc42-antibody-jj086-04_nbp2-67895
View recombinant Rabbit Monoclonal anti-CDC42 Antibody (JJ086-04) ... Reviews & Publications ... Recombinant protein within Human CDC42 aa 30-191 / 191.
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39 Rho GTPase Cdc42 is essential for B-lymphocyte ...
https://ashpublications.org/blood/article/114/14/2909/107844/Rho-GTPase-Cdc42-is-essential-for-B-lymphocyte
Cdc42 is a member of the Rho GTPase family that has been implicated in several ... by the institutional review board of the Cincinnati Children's Hospital.
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40 (PDF) Progress in the therapeutic inhibition of Cdc42 signalling
https://www.researchgate.net/publication/352243580_Progress_in_the_therapeutic_inhibition_of_Cdc42_signalling
PDF | Cdc42 is a member of the Rho family of small GTPases and a key ... In this review, we consider the progress that has been made ...
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41 International Review of Cytology: A Survey of Cell Biology
https://books.google.com/books?id=nhgdNR-hbXgC&pg=PA55&lpg=PA55&dq=cdc42+review&source=bl&ots=Z0q5_EnaVH&sig=ACfU3U3VjLO9Ju0hLEMbM0rZPbRCbv2eTQ&hl=en&sa=X&ved=2ahUKEwjhkNrZ-7j7AhWiQUEAHbvuDBAQ6AF6BQj0ARAD
Monomeric GTPases and Associated Regulators In eukaryotes, monomeric GTPases (i.e., Rac, Cdc42, Rho, Rop) are uniformly required for the establishment and ...
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42 Targeting Rac and Cdc42 GTPases in Cancer. - Europe PMC
https://europepmc.org/article/med/29858187
Rac and Cdc42 are hyperactivated via signaling through oncogenic cell surface ... In this review, we focus on the role of Rac and Cdc42 in cancer and ...
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43 RhoA and Cdc42 in T cells: Are they targetable for T cell ...
https://academic.oup.com/pcm/article/4/1/56/6067386
RhoA and Cdc42 of Rho family small GTPases regulate a variety of cellular functions ... In this brief review, we summarize recent progress in characterizing ...
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44 Overexpression of RhoA, Rac1, and Cdc42 GTPases Is ...
https://aacrjournals.org/clincancerres/article/10/14/4799/181908/Overexpression-of-RhoA-Rac1-and-Cdc42-GTPases-Is
Protein expression of RhoA, ROCK-I, ROCK-II, Rac1, and Cdc42 was significantly ... Institutional Review Board approval was obtained for this ...
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45 Rho GTPase Cdc42 is essential for human T-cell development
https://www.haematologica.org/article/view/5521
Constitutively active mutants of Rac1, Rac2 and Cdc42 all impaired migration towards stromal cell-derived factor-1α and T-cell development to ...
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46 Active Cdc42 Detection Kit#8819 - Cell Signaling Technology
https://www.cellsignal.com/products/cellular-assay-kits/active-cdc42-detection-kit/8819
Assay Kit for studying Cdc42 in the research area. ... Reviews (0). Citations (0). To Purchase # 8819 ... Active Cdc42 Detection Kit: Image 1 Figure 2.
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47 Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
https://www.sigmaaldrich.com/RU/en/product/mm/217708
Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem The Cdc42/Rac1 GTPase Inhibitor, ... find Sigma-Aldrich-217708 MSDS, related peer-reviewed papers, ...
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48 Cdc42 Promotes ADSC-Derived IPC Induction, Proliferation ...
https://www.dovepress.com/cdc42-promotes-adsc-derived-ipc-induction-proliferation-and-insulin-se-peer-reviewed-fulltext-article-DMSO
Cdc42 may promote IPC induction, IPC proliferation and insulin secretion via Wnt/β-catenin ... Review by Single anonymous peer review.
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49 Cdc42 Regulates the Restoration of Endothelial Barrier Function
https://www.ahajournals.org/doi/10.1161/01.res.0000110418.38500.31
In the present study, we examined the role of the Rho GTPases, Rho, Rac, and Cdc42 in the reannealing of AJs. We studied the response to thrombin, ...
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50 CDC42 | Cancer Genetics Web - CancerIndex
http://www.cancerindex.org/geneweb/CDC42.htm
Further top five genes viz Rhoa, PI3KCA, CDC42, MAPK3, TP53 were used for Enrichment ... In this review, we focus on the role of Rac and Cdc42 in cancer and ...
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51 Cdc42 regulates arsenic-induced NADPH oxidase activation ...
https://www.cdc.gov/niosh/nioshtic-2/20025898.html
› niosh › nioshtic-2
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52 Cdc42 Activity Assay Application | BellBrook Labs
https://www.bellbrooklabs.com/products/transcreener-hts-assays/gdp-cdc42-assay/
Mix-and-Read Biochemical HTS Cdc42 Assay. Measure Cdc42 Enzyme Activity with FP, FI, or TR-FRET Readout. ... Sense, in review, validated, in review.
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53 Polarized Exocytosis - CSH Perspectives
https://cshperspectives.cshlp.org/content/9/12/a027870.full
Cdc42 regulates actin dynamics to promote vesicle/tubule formation; ... of Cdc42 to the plasma membrane (for review, see Slaughter et al.
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54 Functional and Therapeutic Relevance of Rho GTPases in ...
https://www.hindawi.com/journals/mi/2021/6655412/
In this review, in addition to the discussion about the role of Rho GTPases (e.g., Cdc42, RhoA, and Rac1) in the neutrophil and macrophage migration and ...
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55 Cdc42 activation state affects its localization and protein levels ...
https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000503?crawler=true
To promote cell polarization, Cdc42 localization and activation need to be precisely regulated both spatially and temporally (for a review see [3]).
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56 Optogenetics reveals Cdc42 local activation by scaffold-mediated ...
https://figshare.com/articles/dataset/Optogenetics_reveals_Cdc42_local_activation_by_scaffold-mediated_positive_feedback_and_Ras_GTPase/11714355
Local activity of the small GTPase Cdc42 is critical for cell polarization. Whereas scaffold-mediated positive feedback was proposed to break symmetry of ...
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57 Filopodia - Wikipedia
https://en.wikipedia.org/wiki/Filopodia
Filopodia (singular filopodium) are slender cytoplasmic projections that extend beyond the ... Activation of the Rho family of GTPases, particularly cdc42 and their ...
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58 Review - CORE
https://core.ac.uk/download/pdf/82312590.pdf
as the Cdc42/Rac1-PAK2 complex (Suzuki et al., 2007). The type II receptors can signal through substrates other than the type I receptors.
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59 Rho-Rac-Cdc42 signaling in cell locomotion - YouTube
https://www.youtube.com/watch?v=O3MqraaLTsc
Animated biology With arpan
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60 Home - NORD (National Organization for Rare Disorders)
https://rarediseases.org/

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61 Reconstituting Cdc42-based polarity establishment - TU Delft
https://www.tudelft.nl/tnw/over-faculteit/afdelingen/bionanoscience/research/research-labs/liedewij-laan-lab/research-projects/reconstituting-cdc42-based-polarity-establishment
Reconstituting Cdc42-based polarity establishment. Saccharomyces cerevisiae proliferates through budding, where a daughter cell grows by budding off one side of ...
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62 20S Proteasome Biological Pathways Reviews | Oncology
https://www.hmpgloballearningnetwork.com/site/onc/biological-pathways-review/20s-proteasome
› site › onc
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