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1 Autism spectrum disorder - Symptoms and causes - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/autism-spectrum-disorder/symptoms-causes/syc-20352928
There may be a connection between children born to older parents and autism spectrum disorder, but more research is necessary to establish ...
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2 Data & Statistics on Autism Spectrum Disorder - CDC
https://www.cdc.gov/ncbddd/autism/data.html
About 1 in 44 children has been identified with autism spectrum disorder (ASD) according to estimates from CDC's Autism and Developmental ...
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3 Autism Spectrum Disorder Fact Sheet
https://www.ninds.nih.gov/autism-spectrum-disorder-fact-sheet
Twin and family studies strongly suggest that some people have a genetic predisposition to autism. Identical twin studies show that if one twin is affected, ...
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4 What Causes Autism In Children? 6 Facts You Need to Know
https://www.parents.com/health/autism/facts/6-facts-you-need-to-know-about-autism/
"If someone is susceptible to [autism, or] ASD because of genetic mutations, then certain situations might cause autism in that person," NIH ...
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5 How pregnancy may shape a child's autism | Spectrum
https://www.spectrumnews.org/features/deep-dive/pregnancy-may-shape-childs-autism/
Autism has been tied to events throughout pregnancy, including the first few days after conception. Even before a tiny human blastocyst attaches ...
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6 What causes autism? | Raising Children Network
https://raisingchildren.net.au/autism/learning-about-autism/about-autism/causes-of-asd
Other factors and autism · older parents · poor growth of the foetus in the womb · lack of oxygen when a baby is born · premature birth · exposure to ...
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7 What is autism? - NHS
https://www.nhs.uk/conditions/autism/what-is-autism/
Being autistic does not mean you have an illness or disease. It means your brain works in a different way from other people. It's something you're born with.
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8 April is National Autism Awareness Month | March of Dimes
https://www.marchofdimes.org/find-support/blog/april-national-autism-awareness-month
Some children with ASD develop normally until they're around 18 to 24 months old, but then they stop gaining new skills or lose the skills they ...
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9 Autistic children may inherit DNA mutations from their fathers
https://www.science.org/content/article/autistic-children-may-inherit-dna-mutations-their-fathers
Now, a new study probing so-called noncoding DNA has found that alterations in regions that regulate gene activity may also contribute to autism. And ...
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10 Causes of autism | Autism Awareness Australia
https://www.autismawareness.com.au/understanding-autism/causes
What causes autism? · Autism is strongly genetic · Older parents may be a factor · Pregnancy and birth · Environmental causes.
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11 Birth related parameters are important contributors in autism ...
https://www.nature.com/articles/s41598-022-18628-4
Autism spectrum disorders is a group of childhood onset neurodevelopmental disorders affecting millions of children across the globe.
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12 Causes of autism - Wikipedia
https://en.wikipedia.org/wiki/Causes_of_autism
BackgroundEdit · Autism involves atypical brain development which often becomes apparent in behavior and social development before a child is three years old.
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13 Autism (ASD): Symptoms, Causes, Tests, Treatment & More
https://www.healthline.com/health/autism
As they interact with others, autistic children might have difficulty sharing their emotions and interests with others or find it hard to ...
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14 Quick Guide to Autism Spectrum Disorder - Child Mind Institute
https://childmind.org/guide/autism-spectrum-disorder-quick-guide/
What is autism spectrum disorder? ... disorder. It affects children in two big ways. First, it can make it harder for them to communicate and ...
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15 Autism - World Health Organization (WHO)
https://www.who.int/news-room/fact-sheets/detail/autism-spectrum-disorders
It is estimated that worldwide about one in 100 children has autism(1). This estimate represents an average figure, and reported prevalence ...
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16 Does My Child Have Autism? - HelpGuide.org
https://www.helpguide.org/articles/autism-learning-disabilities/does-my-child-have-autism.htm
Babies may be born with a genetic vulnerability to autism that is then triggered by something in the external environment, either while he or she is still ...
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17 How likely is it that I could have another child with autism?
https://asatonline.org/research-treatment/clinical-corner/recurrence-of-autism-in-families/
Rather than including all children in a given region, some research focuses only on children with ASD and their siblings. Studies that include all siblings born ...
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18 Can Autism Be Prevented? - WebMD
https://www.webmd.com/brain/autism/can-you-prevent-autism
Doctors don't know what causes autism, but they believe genes play the biggest part in whether a child is born with it.
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19 Autism Risks Related to Pregnancy and Birth - Verywell Health
https://www.verywellhealth.com/autism-risks-in-pregnancy-birth-5207680
A number of studies have found a correlation between preterm birth and autism, as well as other developmental disorders.3 About 7% of children ...
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20 Where does autism come from when it doesn't run in the family?
https://www.cshl.edu/labdish/where-does-autism-come-from-when-it-doesnt-run-in-the-family/
A key fact has come to light within the last couple of years: many autism-causing genetic mutations are “spontaneous.” They occur in the affected child, but in ...
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21 The Link Between Autism and Prematurity
https://sparkforautism.org/discover_article/autism-and-prematurity/
People who were born prematurely are much more likely to be diagnosed with autism than people who were born on time, according to a huge new ...
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22 Autism Spectrum Disorder (for Parents) - Nemours KidsHealth
https://kidshealth.org/en/parents/pervasive-develop-disorders.html
The exact cause of ASD is unknown. It's likely that many different things in combination lead to changes in the way the brain develops before a baby is born.
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23 Month of birth and risk of autism spectrum disorder - BMJ Open
https://bmjopen.bmj.com/content/7/11/e014606
Mean age at ASD diagnosis was 3.0 years (SE=0.07 years). The highest incidences of ASD were recorded among children born in May and August: 10.3 and 10.2 per ...
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24 Can I Find Out What Caused My Child's Autism?
https://www.tpathways.org/faqs/what-caused-my-childs-autism/
What Environmental Factors Might Raise the Risk of Autism? · Conceiving the child at an advanced age · Very low birth weight · Exposure to ...
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25 Birth seasonality and risk of autism spectrum disorder
https://link.springer.com/article/10.1007/s10654-019-00506-5
Season of birth has been hypothesized to be a risk factor for autism spectrum disorder (ASD). However, the evidence has been mixed and ...
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26 Study Says Birth Spacing Can Impact Autism Diagnosis
https://www.verywellfamily.com/study-says-birth-spacing-can-impact-autism-diagnosis-5200984
The Centers for Disease Control and Prevention estimates that one in 54 children has been diagnosed with autism spectrum disorder. A number of ...
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27 Autism Prevention: Is It Possible? - Psych Central
https://psychcentral.com/autism/how-to-prevent-autism
Exposure to contaminants like certain pesticides or air pollution while pregnant may increase the chance that your child may be born autistic.
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28 Small increase in risk of autism seen for pre- and post-term ...
https://www.sciencedaily.com/releases/2020/09/200922144319.htm
Within that cohort, 1.44 percent of the children were diagnosed with ASD, and 4.7 percent were born pre-term -- before 37 weeks of gestation.
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29 Behavioral characteristics of autism spectrum disorder in very ...
https://molecularautism.biomedcentral.com/articles/10.1186/s13229-019-0282-4
Lower gestational age may increase autism spectrum disorder (ASD) vulnerability; however, the incidence of ASD diagnosis through a direct ...
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30 Prevention of Autism: Is it Possible?
https://www.appliedbehavioranalysisprograms.com/faq/what-can-be-done-to-prevent-autism/
A study in the Molecular Psychiatry journal found that autism rates are 15 percent higher in children born to mothers in their 40s and 66 percent higher for ...
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31 What are the Early Signs of Autism? - HealthyChildren.org
https://www.healthychildren.org/English/health-issues/conditions/Autism/Pages/Early-Signs-of-Autism-Spectrum-Disorders.aspx
​Many children with autism spectrum disorder (ASD) show developmental differences when they are babies—especially in their social and ...
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32 7 Risk Factors for Autism - Healthgrades
https://www.healthgrades.com/right-care/autism/7-risk-factors-for-autism
The age of the parents seems to affect a child's risk of ASD. For instance, autism rates are higher among children born to dads older than 50. Genetic mutations ...
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33 UCLA study: Mother's place of birth is a risk factor for autism in ...
https://newsroom.ucla.edu/releases/ucla-study:-mother-s-place-of-birth-is-a-risk-factor-for-autism-in-u-s-born-children
UCLA researchers found that when compared with children born to white American mothers, children of foreign-born women who are black, ...
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34 Association Between Screen Time Exposure in Children at 1 ...
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2788488
... and the development of autism spectrum disorder at 3 years of age. ... This study included children born to women recruited between ...
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35 What Causes Autism Spectrum Disorder and Why Are More ...
https://www.center4research.org/what-causes-autism-spectrum-disorder-and-why-are-more-and-more-kids-being-diagnosed-with-it/
Among children who are 8 years old, ASD diagnoses have more than tripled from 1 in 150 (for children born in 1992) to 1 in 44 for children born in 2010.
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36 Autism in babies: Signs, diagnosis, and next steps
https://www.medicalnewstoday.com/articles/autism-in-babies
What are the signs of ASD in babies? · Lack of eye contact and joint attention · Not responding to their name · Difficulty with nonverbal ...
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37 8 Signs of Autism in Infants - The Mifne Center
https://mifne-autism.com/8-signs-of-autism-in-infants/
There are babies with attachment and communication development disorders whose motor development is swift, but very often babies exhibit hypotonia (low muscle ...
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38 Age, Order, and Autism | On Wisconsin Magazine
https://onwisconsin.uwalumni.com/on_campus/age-order-and-autism/
A child's chances of developing autism may be set at birth, but not necessarily by genetics. According to a study led by UW pediatrics and population health ...
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39 What Are the Possible Causes of Autism?
https://www.autismparentingmagazine.com/what-are-the-possible-causes-of-autism/
Preterm delivery or babies born before 35 weeks are also at risk of developing autism later in life. A recent study found that 26 percent of preterm babies ...
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40 Both preterm and post-term birth increases risk of Autism ...
https://www.efcni.org/news/both-preterm-and-post-term-birth-increases-risk-of-autism-spectrum-disorder/
The causes of autism spectrum disorder (ASD) are complex and remain unclear. A recent study, involving more than 3.5 million children, ...
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41 More Evidence That Parents' Ages Could Influence Autism Risk
https://www.npr.org/sections/health-shots/2015/06/10/413205921/more-evidence-that-parents-ages-could-influence-autism-risk
Autism rates were 18 percent higher among children born to teen moms than among kids born to moms in their 20s. And when the gap between a ...
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42 Are children born with or do they develop autism? - Quora
https://www.quora.com/Are-children-born-with-or-do-they-develop-autism
People are born with, or without, autism. It normally becomes apparent only after a year or so, because by the time the baby has become a toddler then any ...
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43 Causes and Prevalence Rates - Operation Autism
https://operationautism.org/autism-101/causes-and-prevalence-rates/
Indeed, a number of parents of children with autism believe that there is a link between autism and the MMR vaccine (injection of a mixture of three live ...
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44 Cohort effects explain the increase in autism diagnosis among ...
https://academic.oup.com/ije/article/41/2/495/692291
For example, individuals born in 2003 have 16.6 times the odds of an autism diagnosis compared with those born in 1992 [95% confidence interval ...
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45 Early detection of autism in children has improved, but ... - CNN
https://www.cnn.com/2021/12/02/health/autism-early-detection-cdc/index.html
Overall in 2018, about 1 in 44 8-year-olds (2.3% of 8-year-olds) had been identified with autism spectrum disorder, according to one of the CDC ...
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46 US researchers find link between age, birth order and autism
https://www.theguardian.com/lifeandstyle/2009/jan/07/autism-birth-order-parents-age
Parents whose first child is autistic generally do not continue to have other children. The correlation seen with firstborn children is simply a ...
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47 Autism Spectrum Disorder (ASD) - What to Expect
https://www.whattoexpect.com/family/the-autism-spectrum-disorder
Autism spectrum disorder is diagnosed in about 1 in 44 children in this country by the time they are 8 years old — and boys are three to four ...
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48 Early Neurodevelopmental Trajectories for Autism Spectrum ...
https://publications.aap.org/pediatrics/article/146/4/e20200297/79707/Early-Neurodevelopmental-Trajectories-for-Autism
Children born preterm are at high risk for autism spectrum disorder (ASD). However, there is still a lack of appropriate developmental ...
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49 Is autism caused by either mother or father? - Elite Ayurveda
https://eliteayurveda.com/blog/is-autism-caused-by-either-mother-or-father/
Genes that alter during pregnancy alter the child's susceptibility to autism. There are several gene mutations that can be passed on by a parent ...
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50 Autism spectrum disorder: MedlinePlus Genetics
https://medlineplus.gov/genetics/condition/autism-spectrum-disorder/
From as early as 1 to 2 years of age, people with ASD have an impaired ability to interact with other people; they are often more comfortable ...
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51 'Preemie' babies more vulnerable to autism diagnosis later
https://medicalxpress.com/news/2021-08-autism-spectrum-disorder-preterm-early-term.html
Babies born prematurely, even just a couple weeks early, may be at increased risk of autism, a large new study suggests.
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52 Interacting with a Child Who Has Autism Spectrum Disorder
https://www.stanfordchildrens.org/en/topic/default?id=interacting-with-a-child-who-has-autism-spectrum-disorder-160-46
Autism spectrum disorder (ASD) is a developmental disorder. It affects how children interact and communicate with others. The disorder is called a spectrum ...
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53 Autism Spectrum Disorder (ASD) - Cleveland Clinic
https://my.clevelandclinic.org/health/diseases/8855-autism
The truth is that genetics do play a role in autism. When one child is diagnosed with ASD, the next child to come along has about a 20% greater ...
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54 Causes - Autism Society.
https://www.autism-society.org/what-is/causes/
It also appears that some children are born with a susceptibility to autism, but researchers have not yet identified a single “trigger” that ...
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55 Autism Linked to Moms Who Give Birth at 35 or Older or Being ...
https://healthcare.utah.edu/publicaffairs/news/archive/2009/BilderAutism.php
SALT LAKE CITY - Children who are firstborn or breech or whose mothers are 35 or older when giving birth are at significantly greater risk for ...
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56 Can Birth Injury Cause Autism? | Raynes & Lawn
https://rayneslaw.com/can-birth-injury-cause-autism/
The researchers found that those children exposed to complications during childbirth were 10% likelier to develop autism while those who were ...
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57 Mode of delivery, order of birth, parental age gap and autism ...
https://www.cell.com/heliyon/pdf/S2405-8440(20)31911-3.pdf
Rising prevalence of autism spectrum disorders (ASD) in the last decades has ... risk of autism; 61% increase in risk of ASD among the first-born children.
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58 About Autism - UNFINISH3D PIECES
https://unfinish3dpieces.org/about/
Diagnosing ASD can be difficult since there is no medical test, like a blood test, to diagnose the disorders. Doctors look at the child's behavior and ...
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59 Higher Risk of Autism Found in Babies Born Prematurely ...
https://health.mountsinai.org/blog/higher-risk-of-autism-found-in-babies-born-prematurely-according-to-a-definitive-new-mount-sinai-study/
Premature birth is linked to an increased risk of autism spectrum disorder (ASD) in both males and females, with those born earliest ...
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60 Autism Symptoms in Children | Are You Born With Autism?
https://www.pinegrovetreatment.com/blog/2022/04/autism-symptoms-in-children/
Autism spectrum disorder is a condition that develops in childhood and may eventually cause behavioral, social and communication problems.
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61 How Age Differences Between Siblings Can Affect Autism Risk
https://time.com/4033506/autism-risk-siblings/
For children conceived less than 12 months or more than 72 months after the birth of an older sibling, the risk of autism was two to three fold ...
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62 Autism Signs in Infants
https://lighthouseautismcenter.com/blog/top-signs-your-infant-may-have-autism/
Do they reach up toward you to be picked up? Disinterest in seeking a loved one's attention or bonding with a caregiver is a sign your baby may ...
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63 Autism Causes
https://www.autismcenter.org/autism-causes
The onset of autism in a child likely occurs long before developmental delays or behaviors emerge, quite possibly before a child is born. For many children ...
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64 Autism Prevalence Now 1 in 88 children, 1 in 54 boys
https://nationalautismassociation.org/autism-prevalence-now-1-in-88-children-1-in-54-boys/
Today's study, conducted by the Autism and Developmental Disabilities Monitoring (ADDM) Network office of the CDC, looked at eight-year-old children born in ...
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65 Children in Norway born to immigrant mothers have 7 times ...
https://www.zmescience.com/science/news-science/children-in-norway-born-to-immigrant-mothers-have-7-times-the-autism-rate-but-scientists-arent-sure-why/
ASD is a collective term for diagnoses such as autism (childhood autism), Asperger's syndrome, atypical autism, and other autistic traits. The ...
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66 Small Risk of Autism Seen in Babies Born Preterm and Post ...
https://www.awomansview.com/resources/small-risk-of-autism-seen-in-babies-born-preterm-and-post-term/
Of the children born at term (37 to 42 weeks), 0.83% were diagnosed with autism. The autism rates were 1.67% for those born at 22 to 31 weeks; ...
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67 Pregnancy spacing may affect odds of ASD
https://www.autism.org/pregnancy-spacing-may-affect-odds-of-asd/
Across the general population, this study also showed that children born to mothers who became pregnant again three months after giving birth had a 50 percent ...
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68 The causes of autism - National Autistic Society
https://www.autism.org.uk/advice-and-guidance/what-is-autism/the-causes-of-autism
Evidence suggests that autism may be genetic. Scientists have been attempting to identify which genes might be implicated in autism for some years. Autism is ...
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69 Autism Spectrum Disorder in Children - Health Encyclopedia
https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=90&ContentID=P02556
What causes ASD in a child? · Being exposed to toxins in the environment before or after birth · Severe infections such as meningitis or encephalitis that result ...
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70 U.S. Autism Rates Up 10 Percent in New CDC Report
https://publichealth.jhu.edu/2020/us-autism-rates-up-10-percent-in-new-cdc-report
Researchers at the Johns Hopkins Bloomberg School of Public Health contributed to a new CDC report that finds the prevalence of autism ...
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71 Parental Birth Abnormalities and Offspring's Autism Linked
https://medicine.yale.edu/news-article/parental-birth-abnormalities-and-offsprings-autism-linked/
In a study of medical registry records of nearly 400,000 parent-child pairs from Denmark, a Yale School of Public Health study found that ...
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72 Study: As Many As 1 in 40 U.S. Children Has Autism
https://drexel.edu/news/archive/2018/december/asd-1-in-40-children
As many as 1 in 40 children in the United States have been diagnosed with autism, according to a new report from the U.S. Department of ...
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73 U.S. Kids Born in Polluted Areas More Likely to Have Autism
https://www.scientificamerican.com/article/us-kids-born-in-polluted-areas-more-likely-to-have-autism/
Women who live in areas with polluted air are up to twice as likely to have an autistic child than those living in communities with cleaner air, ...
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74 Fragile X is a common cause of autism and intellectual disability
https://health.ucdavis.edu/welcome/features/2012-2013/08/20120822_fragile-X.html
Like classically autistic children, they may avoid eye contact, flap their hands, and have late speech development with unusual patterns, such as mumbling or ...
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75 History of Pregnancy and Birth of Children with Autism ...
https://www.maejournal.com/article/history-of-pregnancy-and-birth-of-children-with-autism-syndrome-disorder-asd
The factors that lead to the birth of children with ASD are the mother's age during the first pregnancy, bleeding, the birth process, age of pregnancy of the ...
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76 The link between autism and older parents is clear, but the ...
https://www.washingtonpost.com/national/health-science/the-link-between-autism-and-older-parents-is-clear-but-the-why-is-not/2017/12/15/dbe03284-dc62-11e7-b859-fb0995360725_story.html
Since then, scientists have conducted similar analyses of data on children born in California, Denmark and Sweden, as well as of an ...
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77 Diagnosing Autism in the Pandemic - The New York Times
https://www.nytimes.com/2021/03/01/well/family/diagnosing-autism-in-the-pandemic.html
Autism spectrum disorder is often suspected when young children stand out as being different from their peers. That can be much harder in ...
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78 Autism linked to difficult birth - Los Angeles Times
https://www.latimes.com/health/la-xpm-2011-jul-11-la-heb-autism-difficult-birth-20110711-story.html
Autism seems to have a powerful genetic component, but a family history of the disorder isn't the whole story. The circumstances of a baby's ...
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79 Pre-Existing Differences in Mothers of Children with Autism ...
https://www.intechopen.com/books/recent-advances-in-autism-spectrum-disorders-volume-i/pre-existing-differences-in-mothers-of-children-with-autism-spectrum-disorder-and-or-intellectual-di
Before the birth of their affected children, certain socio-demographic, health and physical attributes differentiate mothers of children with ASD and/or ID from ...
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80 Does Watching Television Trigger Autism? | NBER
https://www.nber.org/bah/does-watching-television-trigger-autism
Diagnoses of autism have risen dramatically over the past few decades, from an estimated one in 2500 children thirty years ago to one in 150 today.
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81 A Lost Generation: Growing Up With Autism Before The ...
https://www.kennedykrieger.org/stories/interactive-autism-network-ian/lost-generation-growing-up-autism-before-epidemic
When she was born in 1968, autism was a diagnosis reserved for children with severe developmental delays. ... Experts believed autism affected ...
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82 Parents who were born premature likely to have children with ...
https://www.techexplorist.com/parents-born-premature-likely-children-autism/37195/
Parental birth abnormalities and offspring's autism-linked. ... It is well known that the child's preterm birth and low birth weight are risk ...
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83 Preterm and early term birth linked to an increased risk of autism
https://www.mdedge.com/pediatrics/article/244432/neurology/preterm-and-early-term-birth-linked-increased-risk-autism
They found that 6.1% of those born extremely preterm were diagnosed with autism. Meanwhile, autism spectrum disorder prevalences were 2.6% ...
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84 Parent Age and Autism Risk | RxWiki
https://www.rxwiki.com/news-article/autism-risk-may-be-higher-children-born-teen-moms-and-older-parents
A new study found that autism rates increased among children born to teen moms, children born to older parents and among children whose parents ...
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85 3 Factors That Decidedly Do Not Cause Autism - Fatherly
https://www.fatherly.com/health/this-is-what-really-causes-autism-what-doesnt
Premature or traumatic birth also increases the chances of someone being autistic, but those factors also put kids at higher risk of other ...
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86 Birth order and reproductive stoppage in families of children ...
https://www.tandfonline.com/doi/full/10.1080/24750573.2018.1457489
Autism spectrum disorder (ASD) is a developmental disorder characterized by impairment in social interactions and communication accompanied with restricted ...
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87 Examining the Causes of Autism | Dana Foundation
https://www.dana.org/article/examining-the-causes-of-autism/
The researchers concluded that autism and other neurodevelopmental disorders have a strong genetic component. But environmental factors must ...
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88 Can Birth Injury Cause Autism? Here's How the Two Are Linked
https://www.thevillarifirm.com/2020/11/can-birth-injury-cause-autism-here-s-how-the-two/
Studies of American children suggest autism spectrum disorder may be more likely to co-occur in children with birth injuries like cerebral ...
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89 A Guide to the Signs of Autism in Infants
https://autismdfw.org/a-guide-to-the-signs-of-autism-in-infants/
Babies that fall on the autism spectrum will typically have a delay in their social ques, motor skills, verbal skills, and have what seems like ...
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90 How to Prepare a Child with Autism for a New Sister or Brother
https://360behavioralhealth.com/how-to-prepare-a-child-with-autism-for-a-new-sister-or-brother/
Remember that every child with autism is different, and each will react differently to a new sibling. At one extreme, some children will be ...
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91 Potential biomarker for autism identified in infants
https://medicine.wustl.edu/news/potential-biomarker-for-autism-identified-in-infants/
The researchers found that babies diagnosed with autism later in childhood had in their cerebrospinal fluid, as infants, very low levels of ...
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92 Genetic Causes and Modifiers of Autism Spectrum Disorder
https://www.frontiersin.org/articles/10.3389/fncel.2019.00385/full
Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental disorders, affecting an estimated 1 in 59 children.
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93 What Causes Autism? | Everyday Health
https://www.everydayhealth.com/autism/what-causes-autism-here-are-possible-genetic-environmental-risk-factors/
“You can find autism in children who come from parents who may be quite healthy, who might not exhibit any signs of ASD,” he says. “But on the genetic side, the ...
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94 Autism more severe in kids born early or late - Futurity
https://www.futurity.org/autism-more-severe-in-kids-born-early-or-late/
“Normal gestation age of birth seems to mitigate the severity of autism spectrum disorder symptoms, and the types of autistic traits tend to be ...
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95 Autism 'begins long before birth' - BBC News
https://www.bbc.com/news/health-26750786
Scientists say they have new evidence that autism begins in the womb. Patchy changes in the developing brain long before birth may cause ...
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